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The Technological Frontier of Longevity

In this issue, we focus on three pivotal areas of longevity science that are garnering significant attention and investment.
BrainHQ Double Decision Exercise - Longevity Technology

First, we present an in-depth look at the pioneering efforts of Marco Quarta and his team at Rubedo Life Sciences. Quarta’s lifelong dedication to understanding and mitigating the effects of aging has led to innovative approaches in cellular senescence and regenerative medicine.

Next, we delve into the rapidly growing industry of biological age testing. Companies like Generation Lab are at the vanguard of this movement, offering cutting-edge tests that go beyond chronological age to provide insights into one’s biological age. By leveraging epigenetic markers, these tests reveal how lifestyle, environment, and behavior influence aging.

Finally, we examine a landmark study on brain training and its impact on fall prevention among older adults. Falls are a major health concern for the elderly, often leading to severe injuries and substantial healthcare costs. The ACTIVE Study’s findings, based on a decade of research, demonstrate that specific brain training exercises can significantly reduce the risk of falls by improving cognitive processing speeds.

Why should we turn back the clock on ageing?

Marco Quarta, co-founder and CEO of Rubedo Life Sciences, has been a trailblazer in the field of longevity research since childhood. 

His dedication to combating age-related diseases led to the founding of Rubedo, where the focus is on addressing cellular senescence—a primary cause of chronic inflammation and tissue degeneration as we age. 

Cellular senescence, often described as the accumulation of “zombie cells,” drives the biological aging process, particularly after the age of 65, leading to a higher risk of multiple age-related diseases.

Quarta emphasizes the socio-economic necessity of maintaining a young biological age to prevent the unsustainable healthcare costs associated with an aging population.


By delaying the onset of chronic conditions such as Alzheimer’s, diabetes, and cardiovascular diseases, longevity medicines could save trillions in healthcare expenses globally.

Rubedo’s innovative drug discovery platform, Alembic, utilizes cutting-edge single-cell multi-omics and AI to identify and target specific senescent cells. This approach, combining advanced computational chemistry and machine learning, aims to develop precise and safe senolytic drugs.

The challenges in this field, primarily related to the selectivity and safety of targeting senescent cells, are being addressed through continuous technological integration.

Events like LEAP play a crucial role in fostering cross-disciplinary innovations, accelerating progress in the longevity sector. Quarta’s vision of longevity not only focuses on extending lifespan but also on enhancing the quality of life, ensuring the elderly remain active and productive members of society.

Read the full article here.

The booming business of discovering your biological age

Generation Lab, co-founded by longevity researchers from UC Berkeley, is revolutionizing the way we understand aging through its new at-home molecular aging test.

This test, which uses epigenetic markers to measure biological age, offers insights into how lifestyle, environment, and behavior impact aging.

With a price tag starting at $400 per year, the test has attracted over 1,000 early adopters eager to learn about their biological age and take proactive steps to slow the aging process.

The test analyzes biological noise—minor molecular signals that can indicate the early stages of cellular damage and disease risk—across 19 bodily systems.

Fortune Well

This detailed analysis allows for the development of personalized health plans aimed at mitigating specific risks. While the price and the nascent stage of this technology have raised concerns among researchers about accessibility and accuracy, the potential benefits are substantial.

These tests can guide users toward effective lifestyle changes and medical interventions, potentially delaying or preventing age-related diseases.

The growing interest in biological age testing reflects a broader trend in the $26 billion longevity industry, driven by a desire to optimize health and slow aging.

Influential figures in the field, such as David Sinclair and Peter Diamandis, advocate for the use of these tests alongside actionable steps to improve healthspan.

Read the full article here.

Large study finds brain training can reduce falls in older adults

A decade-long study has demonstrated that specific brain training exercises can significantly reduce the risk of falls among older adults.

Conducted by the ACTIVE Study researchers, this study involved over 2,800 older adults and used the BrainHQ app developed by Posit Science.

The study found that participants engaged in speed-of-processing brain training experienced a 31% reduction in fall risk compared to the control group.

Falls are a major concern for older adults, leading to serious injuries and substantial healthcare costs. The Centers for Disease Control reports that falls result in approximately 3 million emergency room visits annually in the U.S., costing around $50 billion.

Longevity Technology

The ACTIVE Study’s findings highlight the critical role of cognitive function in fall prevention. Slower brain processing speeds, which naturally decline with age, are a key risk factor for falls. Brain training exercises that improve processing speed can enhance balance and mobility, providing extra milliseconds to react and prevent a fall.

The results of this study support the integration of cognitive training into fall prevention strategies for older adults. BrainHQ exercises have shown benefits across various cognitive and real-world performance measures, making them a valuable tool for maintaining healthspan.

As healthcare providers recognize the preventative benefits of cognitive training, such programs are becoming more widely available through Medicare Advantage plans and medical centers.

Read the full article here.

Final Thoughts

The convergence of advanced technologies and innovative research is reshaping the longevity landscape, offering promising solutions to the challenges of aging.

Marco Quarta’s work at Rubedo Life Sciences underscores the potential of targeting cellular senescence to extend healthy lifespan and reduce healthcare costs. The rise of biological age testing, exemplified by Generation Lab, highlights a growing consumer interest in personalized health insights and proactive aging strategies.

Meanwhile, the ACTIVE Study’s findings on brain training provide a compelling case for incorporating cognitive exercises into preventative health measures for older adults.

These developments indicate a broader trend towards holistic and personalized approaches to aging, where technological advancements play a pivotal role.

As the longevity industry continues to grow, it is essential to balance innovation with accessibility and accuracy, ensuring that these breakthroughs benefit a wide population.

The integration of AI, single-cell technologies, and advanced chemistry in drug development, alongside personalized health plans and cognitive training, illustrates a multi-faceted approach to extending and enhancing life.

By addressing the underlying causes of aging, providing actionable health insights, and enhancing cognitive function, these innovations have the potential to not only extend lifespans but also improve the quality of life for millions.

As we continue to explore and invest in these cutting-edge solutions, the future of aging looks increasingly optimistic.

“The goal is to die young as late as possible.”

Ashley Montagu

Top Longevity Reads

  • Innovation, Inclusion and Interconnected Healthcare (JP Morgan)
  • No longer science fiction, AI and robotics are transforming healthcare (PwC)
  • Artificial intelligence in healthcare: transforming the practice of medicine (PubMed)
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