Longr.io Logo - Your Guide to Longevity and Anti-Aging Science

The Latest Longevity Medicines: Metformin, Rapamycin, and NAD

Today at Longr Reads, our focus shifts to three remarkable agents - Metformin, Rapamycin, and NAD - each heralding a new era in our understanding and approach to aging and longevity.  Metformin, long known for its role in diabetes management, is now being reimagined as a key player in extending human lifespan. Rapamycin, a discovery from the soils of Easter Island, holds the intriguing potential to alter the course of aging at a cellular level. NAD, a cornerstone of cellular processes, presents a promising avenue in combatting age-related decline.
Silhouettes symbolizing longevity-related societal taboos
Challenging Longevity Taboos: Facing the Unspoken in Ageing.

Today at Longr Reads, our focus shifts to three remarkable agents – Metformin, Rapamycin, and NAD – each heralding a new era in our understanding and approach to aging and longevity. 

Metformin, long known for its role in diabetes management, is now being reimagined as a key player in extending human lifespan. Rapamycin, a discovery from the soils of Easter Island, holds the intriguing potential to alter the course of aging at a cellular level. NAD, a cornerstone of cellular processes, presents a promising avenue in combatting age-related decline. 

As we explore the transformative potential of these compounds, we step into a realm where aging is not just delayed but redefined, promising a future where the golden years are not just extended in number but enhanced in quality. We dissect their roles in longevity, treading a path filled with scientific curiosity and cautious optimism, aiming to demystify their impact on the human longevity.

Let’s dive in …


Is Metformin a Wonder Drug? (Vogue)

Metformin, renowned for its efficacy in diabetes management, now stands at the forefront of longevity research.

Esteemed for activating an enzyme closely linked to longevity, this drug shows promising signs of warding off diseases typically associated with aging, such as diabetes, cancer, and cognitive decline. The medical community, buoyed by its potential, eagerly anticipates results from the Targeting Aging with Metformin (TAME) study, which aims to scientifically substantiate Metformin’s role in life extension. 

This shift from a well-known diabetes treatment to a potential longevity enhancer is a testament to the innovative spirit of medical science, eagerly adapting existing treatments to new, groundbreaking purposes.

Reimagining Rapamycin (BigThink)

Rapamycin, originally unearthed as an antifungal compound from the mysterious soils of Easter Island, has intriguingly evolved into a beacon of hope in the field of longevity science. 

This remarkable transition from a humble antifungal to a potential key in unlocking the secrets of aging is a testament to the fluidity and wonder of medical research. Its pivotal role in targeting the mTOR protein, a crucial regulator in cell division and metabolic processes, places Rapamycin at the vanguard of anti-aging therapeutics. 

The drug’s ability to extend lifespan in animal models has not just sparked curiosity but has opened a new realm of possibilities in human health and longevity. As scientists delve deeper into its capabilities, Rapamycin continues to unfold its layers, revealing a spectrum of potential that could be pivotal in our understanding of aging.

NAD – Should You Take It? (Health News)

Nicotinamide adenine dinucleotide, or NAD, a coenzyme intricately woven into the fabric of our cellular processes, emerges as a focal point in the narrative of aging and longevity. 

This molecule, integral to various vital cellular functions, has garnered significant interest for its potential role in mitigating the impacts of aging. As our understanding deepens, the decline of NAD levels with age is being closely examined, with the hypothesis that supplementing it could potentially rewind the cellular clock. 

Research delving into NAD+ and its precursors, such as NMN and niacin, has opened a promising avenue in the longevity field, particularly spotlighting their potential in enhancing vitality, cognitive function, and overall cellular health. The exploration of NAD+ supplementation embodies the dynamic, ever-progressing nature of longevity science.


We have embarked on an enlightening journey through the realms of Metformin, Rapamycin, and NAD, each offering a unique perspective in the pursuit of longevity. 

Metformin, transcending its traditional role as a diabetes medication, now stands at the forefront of aging research. Rapamycin, with its origins in a remote island’s soil, has become a key focus in understanding the complexities of aging at a cellular level. NAD, essential for cellular health, emerges as a vital player in combating the inevitable decline that comes with age. 

These substances, once confined to specific medical uses, now find themselves at the heart of longevity science, holding the potential to redefine our approach to aging and health. As we delve into these compounds’ possibilities, we are reminded of the boundless potential of scientific inquiry and the ever-evolving nature of medical knowledge. 

Until next time, 

The Longr Reads Team


“Research is to see what everybody else has seen, and to think what nobody else has thought.”

Albert Szent-Györgyi, Nobel Prize-winning Physiologist


Longr Reads’ of the Week

  • Best Exercises for Overall Health & Longevity | Dr. Peter Attia & Dr. Andrew Huberman (Youtube)
  • Unlocking the potential of human longevity advanced therapeutics (PwC)
  • The Global Roadmap for Healthy Longevity | National Academy of Medicine (NAM)
Latest
Follow Us
The latest thinking on what matters most in longevity
Sign up for our newsletter

We value your privacy. Your email address will only be used to send you our newsletter and will not be shared with any third parties. You can unsubscribe at any time.

We use cookies to personalise content and ads, to provide social media features and to analyse our traffic.