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Cold Water Therapy, Luxury Retreats, and Longevity Gene Therapy

This sector, dedicated to extending human lifespan and improving the quality of life in later years, has garnered attention from major corporations, biotech startups, and visionary investors.
Cold water therapy - Cosmopolitan

The field is characterized by its potential to revolutionize healthcare and societal structures, offering immense opportunities for economic growth and human well-being.

The longevity industry’s growth is fueled by advancements in technology and a deeper understanding of the biological processes of aging. Key players in the sector are not only focusing on prolonging life but also ensuring that extended years are lived healthily.

This holistic approach to aging involves innovations such as epigenetic testing, data-driven health recommendations, and the development of drugs aimed at preventing age-related diseases.

Today’s first article presents insights from Alina Su, CEO of Generation Lab, on the evolving landscape of healthy aging. The second article outlines the National Academy of Medicine’s (NAM) Global Roadmap for Healthy Longevity, emphasizing the importance of societal investments and global strategies to manage aging populations. The third article focuses on the role of women in the longevity sector, showcasing the efforts of venture capitalists to support female-led startups and ensure gender diversity in longevity research and business.

Cold water therapy … How does it work, and how can it help?

Cold water therapy, a practice that has surged in popularity within the wellness community, involves immersing the body in water at temperatures below 50 degrees fahrenheit.

This method, popularized by figures like Wim Hof, claims a multitude of health benefits, from reducing inflammation to enhancing the immune system. Personal trainer Steven Dick from The Fitness Group explains that the therapy works by constricting blood vessels, which reduces blood flow to the immersed body parts, thereby reducing inflammation and numbing nerve endings. This results in pain relief, alleviated muscle soreness, and improved circulation.

Research supports these benefits. A 2016 study in “Medicine” showed that participants who exercised and then used cold water immersion reported less muscle soreness.


Additionally, a 1996 study in the Czech Republic suggested that repeated cold water immersions could slightly activate the immune system. Another study, published in the “British Medical Journal,” highlighted the potential of cold water swimming as a treatment for depression, noting immediate mood improvements and a sustained reduction in depressive symptoms in a 24-year-old participant resistant to medication.

A 2022 review emphasized the promise of cold water therapy but called for more rigorous testing. The duration and frequency of therapy sessions vary, typically ranging from a few minutes to 15-20 minutes, with frequency depending on individual tolerance and specific health goals.

Safety is paramount, as the sudden strain from cold water can lead to complications like cold water shock or hypothermia. Beginners are advised to start with cold showers and gradually increase the duration and intensity. Consulting a healthcare professional before starting any new regimen is crucial to ensure safety.

Cold water therapy can be done at home, starting with cold showers and progressively moving to colder temperatures. Some enthusiasts might eventually join cold water swimming groups or invest in at-home ice baths. The practice suits those looking for physical and mental health benefits, provided they approach it with caution and proper guidance.

Read the full article here.

Deepak Chopra’s futuristic new retreat

Deepak Chopra’s new venture at RAKxa, a wellness retreat outside Bangkok, represents the frontier of luxury wellness.

RAKxa combines traditional healing methods with cutting-edge technology, offering a holistic approach to health and longevity. Chopra, a prominent figure in the New Age movement, integrates AI and modern diagnostics to enhance wellness practices.

The retreat’s philosophy revolves around personalized health plans that incorporate advanced meditation techniques, detoxification therapies, cryotherapy, hyperbaric chamber therapy, traditional Thai massage, chakra balancing, and more.

The Standard

Chopra advocates for an integrative approach to medicine, blending Western and Eastern practices. He emphasizes that effective medicine should be inclusive, leveraging both modern technology and traditional methods.

At RAKxa, guests can experience comprehensive wellness programs that aim to balance the mind, body, and soul. These programs include extensive diagnostics, tailored treatment plans, and advanced therapies designed to optimize health and longevity.

RAKxa’s focus on longevity aligns with Chopra’s belief in extending not just lifespan but healthspan—the period of life spent in good health. The retreat aims to help individuals live longer, healthier, and more productive lives. By combining AI, education, and holistic practices, RAKxa offers a model for future wellness resorts.

Chopra’s vision extends beyond RAKxa. He is involved in projects like Gelephu in Bhutan, which aims to create a sustainable, tech-integrated mindfulness community. This initiative highlights Chopra’s commitment to democratizing health and making advanced wellness practices accessible to a broader audience.

Read the full article here.

Study: Gene therapy to reverse aging in mice

Rejuvenate Bio’s recent study on partial reprogramming in elderly mice offers promising insights into age reversal and the potential extension of the human lifespan.

Partial reprogramming utilizes Yamanaka factors – four transcription factors that can revert cells to a stem cell state – in a cyclical manner to rejuvenate cells without causing cancer.

The study focused on elderly mice, equivalent to 77-year-old humans, and showed significant health improvements and a 109% increase in lifespan compared to controls.

The research team, led by Noah Davidsohn, found that cyclically induced expression of three Yamanaka factors (OCT4, SOX2, and KLF4) reduced frailty and reversed the epigenetic state of the mice to a younger profile. This approach avoids the oncogenic risks associated with the fourth factor, c-Myc, by excluding it from the therapeutic process.


While the antibiotic-induced system used in mice cannot be directly applied to humans, the study lays the groundwork for developing safe and effective age-reversal therapies.

Rejuvenate Bio aims to translate these findings into human clinical trials within the next five years, focusing initially on specific age-related diseases like decreased immunity, heart disease, and Alzheimer’s. The goal is to eliminate disease states, thereby extending healthspan and potentially lifespan.

The path to human application involves addressing numerous challenges, such as determining the optimal sequence and duration for turning Yamanaka factors on and off. The research team plans to conduct further studies to refine their approach and ensure safety and efficacy in humans.

Rejuvenate Bio’s work represents a significant step toward the practical application of gene therapy for age reversal. By focusing on reversing diseases associated with aging, they aim to improve the quality of life for the elderly, making extended lifespans both healthier and more fulfilling.

Read the full article here.

Final Thoughts

The innovations highlighted in today’s edition illustrate the dynamic interplay between traditional practices and advanced technologies in the quest for longevity.

Cold water therapy, with its roots in ancient practices, demonstrates how simple, natural interventions can offer profound health benefits. Its increasing popularity underscores a growing interest in holistic wellness approaches that complement modern medicine.

Deepak Chopra’s RAKxa retreat exemplifies the future of luxury wellness, where cutting-edge technology meets traditional healing.

This integrative model not only caters to the affluent seeking bespoke health solutions but also sets a precedent for accessible, high-quality wellness care. By combining personalized diagnostics, AI, and holistic practices, RAKxa offers a comprehensive approach to health that could be replicated in other regions, democratizing advanced wellness care.

Rejuvenate Bio’s gene therapy research represents a groundbreaking advancement in the science of aging. The potential to reverse age-related diseases and extend healthspan through partial reprogramming marks a significant milestone in longevity research. As this therapy progresses toward human trials, it holds the promise of transforming how we approach aging and age-related diseases, shifting the focus from mere disease management to genuine age reversal.

These developments collectively signify a paradigm shift in longevity and health. They highlight the importance of an integrative approach that leverages both traditional and modern practices to enhance health and extend lifespans. As research and technology continue to advance, the future of longevity looks promising, with innovative solutions that not only extend life but also improve its quality.

“Science and technology revolutionize our lives, but memory, tradition, and myth frame our response.”

Arthur M. Schlesinger Jr.

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